Abstract

Development and Optimisation of a Green 2-Step Sterospecific Triazol Synthesis

The development of green chemical processes has gained increasing importance since the introduction of the concept 21 years ago. Green alternatives are even more important when speaking of enantiopure synthesis. However, developing an efficent green process comes with obstacles, especially when one wants to carry out SN2 reactions in water. In this paper, we developed and optimised a 2-step sterospecific synthesis However from L-Phenylalanine and yielding (R)-2-(1H-1,2,4-triazol-1-yl)-3-phenylpropanoic acid ((R)-BnTAA), involving a total of 3 SN2 reactions. The reactions was designed to minimize waste Production and match other green chemistry criteria.


Author(s):

Michael Guillot* , Olivier Riant Tom Leyssens



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